Creatine is an interesting molecule that is synthesized in the liver from three amino acids – arginine, methionine and glycine. 95-98% of creatine is stored in the major skeletal muscles of the body while lesser amounts are found in the heart, brain and testes. Once creatine enters the muscle, it is phosphorylated to form creatine phosphate, which is a high-energy substrate that assists in the contraction of the muscle fibers.
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